The 2015–16 West of Scotland Super League Premier Division was the fourteenth Super League Premier Division competition since the formation of the Scottish Junior Football Association, West Region in 2002.
Auchinleck Talbot won the championship on 25 May 2016, claiming a record fifth West of Scotland Super Premier League title.
Pollok and Shettleston were promoted from the Super League First Division, replacing the automatically relegated Clydebank and Cumnock Juniors.
Kirkintilloch Rob Roy claimed a third promotion spot after defeating Shotts Bon Accord in the West Region League play-off.
Kilwinning will replace Shettleston in the 2016–17 West of Scotland Super League Premier Division.