The 2015–16 Women's EHF Champions League was the 23rd edition of the Women's EHF Champions League, the competition for top women's clubs of Europe, organized and supervised by the European Handball Federation.

CSM București won trophy in their European debut season by defeating Győri Audi ETO KC 29–26 in the big final.

[1] 14 teams were directly qualified for the group stage.

[2] All draws held at the European Handball Federation headquarters in Vienna, Austria.

The teams played a semifinal and final to determine the last participants.