The 2015–16 Wyoming Cowgirls basketball team represented the University of Wyoming in the 2015–16 college basketball season.

The Cowgirls were led by thirteenth year head coach Joe Legerski.

The Cowgirls played their home games at the Arena-Auditorium and were members of the Mountain West Conference.

They finished the season 13–16, 6–12 in Mountain West play to finish in a tie for eighth place.

They lost in the first round of the Mountain West women's tournament to San Diego State.