Novak Djokovic defeated Andy Murray in the final, 7–6(7–5), 6–7(4–7), 6–3, 6–0 to win the men's singles tennis title at the 2015 Australian Open.

It was the third consecutive year that the two met at the Australian Open; on each occasion, their encounter went to a fifth set.

Roger Federer's streak of eleven consecutive Australian Open semifinals ended when he lost to Andreas Seppi in the third round.

[3][4] Nick Kyrgios became the first teenager to reach the quarterfinals since Andrei Cherkasov in 1990, and the first Australian to do so since Lleyton Hewitt in 2005.

[5] Kyrgios also became the first teenager to reach multiple major quarterfinals since Rafael Nadal in 2006.