Union Douala picked up a road point with a 1-1 score at New Star, while Cotonsport played a scoreless home tie against Botafogo FC.
With their respective top-two finishes, Cotonsport and Union Douala qualified for the 2016 CAF Champions League.
New Star and Botafogo finished in a third-place tie and will play a play-off to determine the 2016 CAF Confederation Cup qualifier.
Canon, Njala Quan and Tonnerre finished 16th, 17th and 18th, respectively and will be relegated to Elite Two for the 2016 season.
Renaissance, Scorpion de Bé, Sable Batié and Douala AC were all relegated to Elite Two after finishing in the last four spot of the 2014 season.