Defending champion Novak Djokovic defeated Andy Murray in the final, 7–6(7–3), 4–6, 6–0 to win the men's singles tennis title at the 2015 Miami Open.

Djokovic completed his third Sunshine Double with the win, and claimed his fifth Miami Open title.

It was also his second consecutive Sunshine Double.

All seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.