In the state league the club's performance led to semifinals when The Dearest lose to rival Santos in a single match on away field (1-2).

By the continental tournament, Tricolor reach the round of 16 being beaten by Cruzeiro in penalty shootouts by 3-4 after two equal scores (1-0 home; 0–1 away).

In April, Muricy Ramalho left the São Paulo FC due to health problems and the team was trained by assistant coach Milton Cruz during a few matches and managed by Colombian Juan Carlos Osorio and Brazilian Doriva in the course of the season.

The main event of the year was the retirement of goalkeeper Rogério Ceni in a symbolical match between the world champions players by São Paulo in 1992 and 2005.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.