The group stage campaign started disastrously for the Ukrainians, who earned only a single point in their first three games with a 0–0 draw away to Saint-Étienne and 1–0 home defeats to both Inter and Qarabağ.

On matchday 4, a 2–1 away win over the Azerbaijani team ended a winless run, but Dnipro were again defeated by Inter 2–1 in Milan, despite taking a 1–0 lead through Ruslan Rotan's early goal.

Sevilla then played Liège twice, a goalless away draw and a 3–1 home victory with goals from Kevin Gameiro, José Antonio Reyes and Carlos Bacca.

The Spanish side secured second place in the final game with a home victory over Rijeka via Denis Suárez's first European goal.

[21] At the behest of club president José Castro, Sevilla chose to wear their red away kit, featuring their badge rather than the "SFC" monogram which they had previously been sporting.

[22] Although Sevilla dominated possession in the early exchanges, Dnipro opened the scoring after seven minutes when Nikola Kalinić headed in a cross from Matheus.

In the 28th minute, Dnipro failed to clear from a free kick and Sevilla midfielder Grzegorz Krychowiak took possession of the ball, taking a step to evade Léo Matos before shooting an equaliser in his home country.

Only three minutes later, the Spanish club took the lead, when captain José Antonio Reyes, in what was reported to be his final match for Sevilla, found Carlos Bacca who rounded Dnipro goalkeeper Denys Boyko.

Only two minutes before half time, Dnipro equalised, with Ruslan Rotan dispatching a free kick past Sergio Rico.

The two teams then made their last substitutions in the closing stages, Dnipro replaced Jaba Kankava with Yevhen Shakhov and Sevilla took off Éver Banega for Vicente Iborra.

Manager Myron Markevych confirmed that he was treated at hospital for a nasal fracture and a head injury, being discharged in good health hours later to reunite with his teammates.