The team was led by eighth-year head coach Sean Miller, and played their home games at McKale Center in Tucson, Arizona as members in the Pac-12 Conference.

Arizona received as an automatic bid to the 5th straight NCAA tournament (34th NCAA tournament appearances) as a 2-seed in the West regional, The Arizona Wildcats defeated the 15-seed North Dakota 100–82 in the first round, 7-seed Saint Mary's 69–60 in the second round before being upset by 11-seed Xavier 71–73 in the Sweet Sixteen.

The Wildcats entered the Pac-12 tournament as a 4 seed where they beat Colorado in the quarterfinals, but fell in the semifinals to Oregon in overtime.

However, due to eligibility concerns, five-star recruit Terrance Ferguson chose to play internationally and not attend Arizona.

They played Michigan State in the Armed Forces Classic at Joint Base Pearl Harbor–Hickam in Honolulu, Hawaii (later announced that game was moved to Stan Sheriff Center to accommodate more fans[19]), Gonzaga in the first ever HoopHall LA event at Staples Center in Los Angeles, California, Texas A&M at the Toyota Center in Houston, Texas, and also played at Orleans Arena as part in the Las Vegas Invitational in Las Vegas, where they face off against three of the following: Butler, Santa Clara or Vanderbilt.