[2] On 3 June, Barcelona announced that German club Borussia Dortmund have informed them of their desire to activate the buy-out clause for Marc Bartra.

[6] On 12 July, the club announced the transfers of 22-year-old French international defender Samuel Umtiti from Lyon[7] and Lucas Digne from Paris Saint-Germain for the next five seasons, respectively.

[39] On 15 October, Barcelona defeated Deportivo de La Coruña 4–0 with two goals from Rafinha and one each from Luis Suárez and Messi, the latter who returned from injury in the match.

[42] On 29 October, Barcelona won against Granada 1–0 in the 1,500th game at Camp Nou, Barça found it tough to breakdown the stubborn visitors but Rafinha's strike was enough to claim the win.

[44] On 6 November, Barcelona won 1–2 against Sevilla at the Sánchez Pizjuán; Messi canceled out Vitolo's opener late in the first half before setting up Luis Suárez for the winner in a frenetic game.

[49] On 27 November, Barcelona drew 1–1 with Real Sociedad at Anoeta, Messi's second-half leveller halted Barça's run of four straight league losses in San Sebastian.

[50] On 30 November, Barcelona drew Hércules 1–1, a fine long range strike from debutant Aleña gave Barça a slight advantage going into the second leg.

[53] On 10 December, Barcelona won Osasuna 0–3, Luis Suárez breaks the deadlock in the second half, and two further goals from Leo Messi go on to claim all three points in Pamplona.

[57] On 21 December, Barcelona won 7–0 against Hércules; Paco Alcácer scored his first official goal and Arda Turan got a hat-trick as Barça cruised into the last 16 of the Copa del Rey.

[60] On 11 January, Barcelona won 3–1 against Athletic Bilbao, goals from Suárez, Neymar and Messi secured an action-packed victory that kept alive the quest for a third consecutive Copa del Rey trophy.

[61] On 14 January, Barcelona won 5–0 against Las Palmas, a brace from Luis Suárez and one each for Leo Messi, Arda Turan and Aleix Vidal gave Barça a winning home start to the league in 2017.

[65] On 29 January Barcelona drew 1–1 with Real Betis, an incident-packed game saw Suárez snatched a draw in the 90th minute after the Catalans had already seen at least one valid equaliser overruled.

[67] On 4 February, Barcelona won 3–0 against Athletic Club Bilbao, Paco Alcácer, Leo Messi, and Aleix Vidal all found the net.

[68] On 7 February, Barcelona draw 1–1 against Atlético Madrid, Luis Suárez's tap-in just before half-time was enough to see the Catalans into a fourth consecutive Copa del Rey final despite late drama which saw the visitors equalise and a player sent off.

Luis Suárez (2), Neymar Jr, Leo Messi and Ivan Rakitic were on target, plus one own goal; Aleix Vidal suffered a very serious ankle injury late in the game.

[72] On 26 February, Barcelona won 2–1 against Atlético Madrid, Rafinha's opener was quickly cancelled out by Godín's header but Messi sealed three points in the closing stages.

Marc-Andre Ter Stegen's saves coupled with Neymar's brace and Sergi Roberto's goal at the death clinched the 6–5 aggregate win in what was hailed as one of the greatest comebacks in Champions League history.

[78] On 12 March, Barcelona lost to Deportivo la Coruña 2–1, two goals from corners condemned Barça to defeat in Galicia, with Luis Suárez scoring in between.

[81] Barcelona defeated Granada on 2 April 1–4 away, goals from Suárez, Alcácer, Rakitic and Neymar handed Barça another three points to keep in close proximity of the top.

[87] On 23 April, Barcelona beat Real Madrid 3–2, Barça grabbed a dramatic victory at the Santiago Bernabéu thanks to an injury-time strike from Leo Messi to move joint-top of the table.

[92] On 6 May, Barcelona beat Villarreal 4–1, Messi, Suarez and Neymar all scored to keep the Liga title challenge alive, in the process surpassing a combined 100 goals for a third consecutive season.

[94] On 21 May, Barcelona won Eibar 4–2, Luis Enrique's men rally back from two goals down to claim victory on the final day of the league campaign but it was not enough to earn the title.

[95] On 27 May, Barcelona won Alavés 3–1, Barça become the first side since the 1950s to win the Copa del Rey three years in a row, on Luis Enrique's last game in charge.