The 2016–17 FC Lokomotiv Moscow season was the club's 25th season in the Russian Premier League, the highest tier of association football in Russia.

Lokomotiv Moscow participated in and won the Russian Cup, thereby also qualifying to the 2017-2018 UEFA Europa League.

[1]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Awarded monthly to the player that was chosen by fan voting on Lokomotiv's official portal on VK.