The 2016–17 season is FC Sheriff Tiraspol's 20th season, and their 19th in the Divizia Naţională, the top-flight of Moldovan football.

Bruno Irles was appointed as the club's new manager on 20 June 2016.

[1] On 23 September 2016, Bruno Irles' contract was terminated by mutual consent,[2] with Roberto Bordin being appointed the club's new manager on 4 October 2016.

[3] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.