The season began on 19 August 2016 and concluded on 6 May 2017; the relegation play-off took place on 12 May 2017.
On 30 April 2017, Hibernians defeated St. Andrews 3–1 to clinch their 12th Maltese league title.
Naxxar Lions and Qormi were relegated to the 2016–17 Maltese First Division after they finished eleventh and twelfth, respectively, the previous season.
They were replaced by Gżira United and Ħamrun Spartans, champions and runners-up respectively of the 2015–16 Maltese First Division.
Source: Scoresway A play-off match took place between the eleventh-placed team from the Premier League, Mosta, and the fourth-placed team from the First Division, Qormi, for a place in the 2017–18 Maltese Premier League.