The 2016–17 Primera División de Fútbol Profesional season (also known as the Liga Pepsi) is the 18th season and 35th and 36th tournament of El Salvador's Primera División since its establishment of an Apertura and Clausura format.
Should the same team win both tournaments, both runners-up will qualify for CONCACAF League.
Should the final of both tournaments features the same 2 teams, the semifinalist with the better aggregate record will qualify for CONCACAF League.
Atlético Marte were relegated to 2016–17 Segunda División the previous season.
The relegated team was replaced by the 2015–16 Segunda División playoffs promotion winner.
Promoted from Segunda División de Fútbol Salvadoreño as of June, 2016.
Relegated to Segunda División de Fútbol Salvadoreño as of June, 2016.