The 2016–17 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2016–17 NCAA Division I men's basketball season.

The Salukis, led by fifth-year head coach Barry Hinson, played their home games at the SIU Arena in Carbondale, Illinois as members of the Missouri Valley Conference.

In the MVC tournament, they defeated Loyola–Chicago in the quarterfinals before losing to Illinois State in the semifinals.

They lost in the quarterfinals of the MVC tournament to Northern Iowa.

Despite having 22 wins, they chose not to participate in a postseason tournament.