The 2016–17 season was Unione Calcio Sampdoria's 60th season in Serie A, and their 5th consecutive season in the top-flight.

Sampdoria competed in Serie A, finishing 10th, and in the Coppa Italia, where the club was eliminated in the round of 16 by Roma.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: Competitive matches Last updated: 28 May 2017Source: Competitions