The 2016–17 season was Unione Sportiva Città di Palermo's third consecutive season in the top-flight of Italian football.

Palermo competed in Serie A and the Coppa Italia.

Palermo finished the league season in 19th place and were relegated to Serie B.

Players and squad numbers last updated on 31 January 2017.Appearances and goals are counted for domestic leagues (Serie A and Serie B) and national cup (Coppa Italia) and correct as of 28 May 2017.

[2]Note: Flags indicate national team as has been defined under FIFA eligibility rules.