and advanced to the playoffs on the last day of the season, October 2, where they lost to the Blue Jays in the American League Wild Card Game 5–2 in 11 innings; this was the Orioles' third postseason appearance in five years.
Right fielder Mark Trumbo won the MLB and American League home run championships with 47; 2016 was the fourth consecutive year in which an Oriole won the home run crown following Chris Davis in 2013, Nelson Cruz in 2014 and Davis again in 2015.
April 7: St. Louis Cardinals traded LHP Jayson Aquino to Baltimore Orioles for cash.
April 18: Traded LF Alfredo Marte to Philadelphia Phillies for player TBD.
May 16: Toronto Blue Jays claimed DH Jimmy Paredes off waivers from Baltimore Orioles.
May 24: Cincinnati Reds traded RHP Franderlin Romero to Baltimore Orioles for Future Considerations; Contract of LHP Ashur Tolliver selected from AA Bowie.
May 25: Baltimore Orioles signed free agent LHP Brian Duensing to a minor league contract.
June 2: Contract of LHP Brian Duensing selected from AAA Norfolk; Baltimore Orioles signed free agents LHP Hector Jimenez and RHP Wally Vrolijk to a minor league contracts.
July 29: OF Julio Bourbon sent outright to AA Bowie; signed free agent RHP Logan Ondrusek.
August 1: Baltimore Orioles traded C Jonah Heim to Tampa Bay Rays for 2B Steve Pearce.
August 2: Baltimore Orioles activated Steve Pearce and LHP Wade Miley.
August 7: Atlanta Braves claim RHP Chaz Roe off waivers from Baltimore Orioles.
August 28: Baltimore Orioles signed free agent RHP Tommy Hunter.
August 30: CF Julio Borbon and RHP Logan Ondrusek sent outright to AA Bowie.
September 15: Miami Marlins claimed Odrisamer Despaigne off waivers from Baltimore Orioles; Contract of SS Paul Janish selected from AAA Norfolk.
April 25: RHP David Hale and IF Ryan Flaherty optioned to AAA Norfolk.
June 18: LHP T.J. McFarland and RHP Mike Wright optioned to AAA Norfolk.
June 30: RHP Oliver Drake and C Francisco Pena optioned to AAA Norfolk.
July 26: RF Dariel Alvarez optioned to AAA Norfolk; CF Julio Bourbon designated for assignment.
August 28: LHP T.J. McFarland and CF Julio Borbon designated for assignment; RHP Oliver Drake recalled from AAA Norfolk.
April 3: LHP Brian Matusz (left intercostal strain), RHP Kevin Gausman (right shoulder strain), and DH Jimmy Paredes (left wrist sprain) placed on 15-day disabled list, retroactive to March 25.
June 18: SS J.J. Hardy and RHP Yovani Gallardo activated from 15-day disabled list.
September 15: LHP Chris Lee (left shoulder strain) placed on 60-day disabled list.
The Orioles faced the Toronto Blue Jays in the Wild Card Game, losing 5–2 in 11 innings.
The following Orioles were selected to participate in the 2016 Major League Baseball All-Star Game: Infielders Outfielders Other batters Coaches