The 2016 CAF Confederation Cup knockout stage was played from 17 September to 6 November 2016.
[1] A total of four teams competed in the knockout stage to decide the champions of the 2016 CAF Confederation Cup.
In the knockout stage, the four teams played a single-elimination tournament.
If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III.
In the final, the two semi-final winners played each other, with the order of legs decided by an additional draw held after the group stage draw.