The Stampeders qualified for the playoffs for the 12th straight year and advanced to the Grey Cup game where they lost to the Ottawa Redblacks.

This season was Dave Dickenson's first year as head coach after John Hufnagel moved into a strict general manager role.

In the early morning hours of September 25, 2016, Stampeders defensive back Mylan Hicks was shot and killed at a Calgary nightclub.

Fellow defensive back and teammate Jamar Wall changed his jersey number from 29 to no.

As a gesture to his memorial, the pistols that adorned the shoulders of the black alternate jersey were covered up.