[1] Chicago Fire began the regular season on March 6, 2016, with a home match against New York City FC.

This surpassed the New York Red Bulls for the longest road winless streak in MLS history.

The two-years and 28 days long streak finally ended when the Fire defeated Montreal Impact, 3–0, on the road on August 20, 2016.

Source: Chicago Fire official roster Per Major League Soccer and club policies terms of the deals do not get disclosed.

[58][59] Forward/midfielder David Accam was named the team's Most Valuable Player and Golden Boot winner for the second year in a row in both categories.

Tied with Jonathan Campbell for a team-high 33 league appearances, Kappelhof made 85 clearances, 17 blocks and 113 interceptions during his first MLS campaign.