The Indians won the American League Central for the first time since 2007 and also beat the Boston Red Sox in the ALDS for their first playoff win in nine years.
They would get their first win a day later, as newly acquired 1B Mike Napoli hit the go-ahead home run in a 7–6 victory over his former team.
They spent the month battling with the Detroit Tigers, Kansas City Royals, and fading Chicago White Sox atop the AL Central.
SP Danny Salazar, who went 5–0 with a 1.91 ERA and a .177 opponent's batting average, was named the American League Pitcher of the Month for June.
On July 5, SP Danny Salazar and SS Francisco Lindor were named to the All Star team.
However, On August 11, the team opened an 11-game home stand - its longest of the season - that would put them on the winning track.
The Blue Jays series, which was believed to be a potential playoff preview, featured three one-run games including a walk-off inside-the-park home run by OF Tyler Naquin.
On August 31, the team acquired OF Coco Crisp from the Oakland Athletics for cash considerations.
However, the team's rotation, widely believed to be their biggest strength, suffered two major injuries during the month.
All-Star SP Danny Salazar left the game on September 9 with a strained elbow, resulting in a 3-4 week recovery time.
On September 17, SP Carlos Carrasco left the game with a broken hand as the result of a line-drive.
The Indians would face the Toronto Blue Jays in the American League Championship Series, again having home-field advantage.
A. Happ gave the Indians a 1−0 lead, but the Blue Jays tied it in the third with a Josh Donaldson RBI double.
Starter Josh Tomlin, along with Bryan Shaw, Miller, and Allen, would make that 2–1 lead stand up the rest of the game.
Indians' starter Trevor Bauer left the game in the bottom of the inning due to a bloody finger as a result of being cut from a drone before the series started.
Led by Mike Napoli and Jason Kipnis home runs, the Indians won this game 4–2, to take a 3–0 series lead.