The 2016 Copa Luis Villarejo was the first edition of the Copa Luis Villarejo, a cup tournament for clubs in Puerto Rico organized by the Puerto Rican Football Federation.

The champions and runners-up of this tournament are eligible to enter the 2017 Caribbean Club Championship, which serves as a qualifying tournament for the 2017 CONCACAF League and the 2018 CONCACAF Champions League.

Criollos de Caguas FC won 14–2 on aggregate.

Puerto Rico FC won 6–0 on aggregate.

Criollos de Caguas FC won 5–4 on aggregate.