Stan Wawrinka was the defending champion in men's singles, but he lost to Andy Murray in the semifinals.

Serena Williams was the defending champion in the women's singles, but she lost to Garbiñe Muguruza in the final.

Furthermore, nine-time champion Rafael Nadal withdrew during the tournament due to injury, for the first time in his French Open career.

Novak Djokovic's victory at this tournament in his 20th Grand Slam final completed his career Grand Slam of all four major tournaments, the eighth man to do so in singles and the fifth since the start of the Open Era (after Rod Laver, Andre Agassi, Roger Federer, and Rafael Nadal).

Djokovic also achieved a non-calendar year Grand Slam, becoming the first man since Rod Laver in 1969 to hold all four major titles at once.

The following players were accepted directly into the main tournament, but withdrew with injuries, suspensions or personal reasons.