The season began on 12 March 2016 and concluded on 29 October 2016; the relegation play-off took place on 5 November 2016.
FC Kaisar was relegated at the end of the 2015 season, and was replaced by Akzhayik.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.
The number of foreign players is restricted to eight per KPL team.
After completion of the Championship round the winners will be the Champions of 2016 Kazakhstan Premier League and qualify for 2017–18 UEFA Champions League second qualifying round.