The Galaxy finished the MLS regular season third in the Western Conference, but were knocked out by the Colorado Rapids in the Conference Semifinals of the 2016 MLS Cup Playoffs.

They also continued their campaign in the 2015–16 CONCACAF Champions League, reaching the quarterfinals before losing to Santos Laguna.

The team also reached the semifinals of the U.S. Open Cup before being knocked out by FC Dallas.

On September 8, Landon Donovan came out of retirement and signed with the Galaxy, his former club.

Note: Flags indicate national team as defined under FIFA eligibility rules.