The 2016 National Lacrosse League season, the 30th in the history of the NLL,[1] began on January 1, 2016,[2] and ended with the Champion's Cup Finals series on June 4, 2016.

The Saskatchewan Rush won their 2nd straight title; their first while located in Saskatchewan.

Reference: [6] x: Clinched playoff berth; c: Clinched playoff berth by crossing over to another division; y: Clinched division; z: Clinched best regular season record; GP: Games PlayedW: Wins; L: Losses; GB: Games back; PCT: Win percentage; Home: Record at Home; Road: Record on the Road; GF: Goals scored; GA: Goals allowedDifferential: Difference between goals scored and allowed; GF/GP: Average number of goals scored per game; GA/GP: Average number of goals allowed per game *Overtime Awards are presented monthly for the best overall player and best rookie.