Despite winning the Pennsylvania primary, Clinton went on to lose the state to Republican candidate Donald Trump in the general election.

Clinton swept all income and educational attainment levels except for whites without college degrees, whom Sanders won 50–49.

Clinton also won among unions 56–43, a very important demographic in a big manufacturing state like Pennsylvania.

Clinton won large victories in all of Pennsylvania's major cities: she won in Philadelphia 63–37, the affluent Philadelphia suburbs 58–42, and also carried the cities of Pittsburgh and Erie.

Of her victory in Pennsylvania, New York Times analyst Alan Rappeport commented, "Lots of Philadelphia history and imagery coming from Clinton now.