The 2016 S.League (also known as the Great Eastern Yeo's S.League for sponsorship reasons) was the 21st season of the S.League, the top-flight Singaporean professional league for association football clubs, since its establishment in 1996.

The season began on 13 February 2016, and concluded on 28 October 2016.

[4] A total of 9 teams competed in the league.

Albirex Niigata (S) and DPMM FC were invited foreign clubs from Japan and Brunei respectively.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.