The 2016 Scheldeprijs is a one-day semi-classic cycling race that took place in Belgium on 6 April 2016.

[1] Unlike other spring classics such as Paris–Roubaix and the Tour of Flanders, the Scheldeprijs is suited particularly for the sprinters, such as the defending champion, Alexander Kristoff (Team Katusha).

Marcel Kittel (Etixx–Quick-Step) and Mark Cavendish (Team Dimension Data) had both won the race three times.

[2] The finish was changed from previous years, with two extra corners added in the race finale in an attempt to improve safety.

[4] The race was won by Kittel in a sprint finish, with Cavendish second and André Greipel (Lotto–Soudal) third.