It was the 53rd edition of the Trofeo Laigueglia and was rated as a 1.HC event as part of the 2016 UCI Europe Tour.

The champion of the 2015 Trofeo Laigueglia, Davide Cimolai, was not selected as part of the Lampre–Merida team.

[2] He broke away with a small group in the closing kilometres, then attacked on the final climbs.

He held off a small chasing group to take a solo win, with Sonny Colbrelli (Bardiani–CSF) second and Grega Bole (Nippo–Vini Fantini) third.

[4] Eighteen teams were invited to take part in the race.