Incumbent Democratic Senator Patty Murray ran for re-election to a fifth term,[1] and won by a significant margin, winning 59% of the vote, to Republican Chris Vance's 41%.

Under Washington's nonpartisan blanket primary law, all candidates appear on the same ballot, regardless of party.

In the August 2 primary, voters had the choice to vote for any candidate, regardless of their party affiliation.

As of 2024, this is the last time a Democrat running statewide for federal office has won Grays Harbor and Mason counties.

with Rob McKenna with Dave Reichert with Jaime Herrera Beutler with Cathy McMorris Rodgers At 1,913,979 votes, Murray made history by receiving the most votes in a United States Senate election in Washington state.