Louisiana voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, businessman Donald Trump, and running mate Indiana Governor Mike Pence against Democratic Party nominee, former Secretary of State Hillary Clinton, and her running mate Virginia Senator Tim Kaine.

[3] Six of those states, including Louisiana, have not supported any Democratic presidential candidate since Bill Clinton (The other five being Arkansas, West Virginia, Kentucky, Tennessee, and Missouri), while an additional five (Iowa, Ohio, Wisconsin, Michigan, and Pennsylvania) had all voted Democratic at least twice since Bill Clinton's re-election in 1996.

Four candidates appeared on the Republican presidential primary ballot: On March 24, the State Convention met in an attempt to reverse the results of the primary, giving Ted Cruz a clear majority.

Donald Trump carried the state, lengthening the Republican streak in Louisiana to 5 straight contests.

As a result, this marked the first time since 1992 that East Baton Rouge Parish backed the losing candidate of the election, and the first time since 1948 that East Baton Rouge Parish voted for the Democratic candidate three elections in a row; Trump also became the first Republican to win the White House without carrying this parish since Richard Nixon in 1968.