Oklahoma voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, businessman Donald Trump, and running mate Indiana Governor Mike Pence against Democratic Party nominee, former Secretary of State Hillary Clinton, and her running mate Virginia Senator Tim Kaine.

Twelve candidates appeared on the Republican presidential primary ballot:[7] The following are final 2016 predictions from various organizations for Oklahoma as of Election Day.

Hillary Clinton's vote percentage of 28.9% is the worst for a Democratic candidate in Oklahoma since George McGovern's 24% in the 1972 election.

[19] With 65.32% of the popular vote, Oklahoma would prove to be Trump's third strongest state in the 2016 election after Wyoming and West Virginia.

Republican: David Oldham, Teresa Lyn Turner, Mark Thomas, Bobby Cleveland, Lauree Elizabeth Marshall, Charles W. Potts, George W. Wiland Jr Libertarian: Erin Adams, Mikel Dillon, Joel Britt Dixon, Rex L. Lawhorn, Ephriam Zachary Knight, Craig A. Dawkins, Mark C. DeShazo Democrat: Marq Lewis, Bill John Baker, Mark Hammons, Betty McElderry, W. A.