Zulte Waregem were the defending champions, but they were eliminated by Club Brugge in the Seventh Round.
Standard Liège won the cup, beating Genk after extra time in the final.
The Belgian Cup consists of ten rounds, with teams entering at different points, depending on their 2017-18 League standings.
The draw for the quarter-finals was made on 30 November 2017, immediately after completion of the final match of the Seventh Round.
The final took place on 17 March 2018 at the King Baudouin Stadium in Brussels and was won by Standard Liège.