The 2017–18 EHF Challenge Cup was the 21st edition of the European Handball Federation's third-tier competition for men's handball clubs, running from 7 October 2017 to 20 May 2018.

All draws held at the European Handball Federation headquarters in Vienna, Austria.

The draw for the quarter-final and semi-final pairings was held at the EHF Office in Vienna on 20 February at 11:00 hrs.

AHC Potaissa Turda won 59–56 on aggregate.

AHC Potaissa Turda won 59–49 on aggregate.