The 2017–18 FC Lokomotiv Moscow season was the club's 26th season in the Russian Premier League, the highest tier of the Russian football league system.

Lokomotiv Moscow also took part in the Russian Cup and also the Europa League.

Lokomotiv's farm club was relaunched as Kazanka and participated in the Russian Professional Football League, the third highest division in the Russian football league system.

[4]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Lokomotiv have qualified directly for the group stage of the 2017–18 UEFA Europa League after winning the 2017 Russian Cup Final.