The 2017–18 High Point Panthers women's basketball team represented High Point University during the 2017–18 NCAA Division I women's basketball season.

The Panthers, led by sixth-year head coach DeUnna Hendrix, played their home games at the Millis Athletic Convocation Center as members of the Big South Conference.

They advanced to the semifinals of the Big South women's tournament where they lost to Liberty.

They lost 55–48 in the quarterfinals of the Big South tournament to Presbyterian.

In addition, the road games against Ohio, Duke, Stetson and Virginia Tech were televised on ESPN3, the Norfolk State game was televised on Spartan Showcase Video, and the UNC Greensboro game was televised on SoCon Digital Network.