The Ramblers, led by seventh-year head coach Porter Moser, played their home games at the Joseph J. Gentile Arena in Chicago.

With a win against Evansville on February 18, 2018, Loyola clinched at least a share of its first-ever Missouri Valley Conference regular season championship.

[2] The Ramblers defeated Northern Iowa, Bradley, and Illinois State to win the MVC tournament.

They then defeated Nevada in the Sweet Sixteen and Kansas State in the Elite Eight to advance to the Final Four for the first time since 1963.

The Ramblers' run also made the team's then-98-year-old chaplain Sister Jean a national and even international media figure.