[5][6] At the end of the 2016–17 season, Luton released Stephen O'Donnell, Danny Green, Zane Banton, Craig Mackail-Smith and Liam Gooch.

[7] Jonathan Smith, Josh McQuoid and Jake Gray were placed on the transfer list,[8] with the latter signing for Yeovil Town for an undisclosed fee.

[14][15] Luton made eight summer signings, including goalkeepers Marek Štěch from Sparta Prague,[16] James Shea from AFC Wimbledon,[17] Harry Isted from Stoke City,[18] defender Jack Stacey from Reading,[19] midfielders Alan McCormack from Brentford,[20] Andrew Shinnie on loan from Birmingham City,[21] and strikers James Collins from Crawley Town,[22] and Elliot Lee from Barnsley.

[23] In terms of backroom staff, Luton chairman Nick Owen, who had fronted the consortium that took over and stabilised the club in 2008, announced he was to step down from the position on 3 August.

[24] Luton began the season at home to Yeovil Town and won the match 8–2, the club's biggest Football League victory since a 6–0 win over Crewe Alexandra in December 1996.

[35] Luton were knocked out of the EFL Cup in the first round after being beaten 2–0 at home to Championship club Ipswich Town, who scored in each half through David McGoldrick.

[38] Luton suffered their first league defeat of the season after losing 1–0 to Barnet, who scored in second-half stoppage time through Jack Taylor with a 25-yard curling shot.

[59] Berry made it 3–0 with a shot into the bottom corner on 21 minutes, before Ben Kennedy pulled one back for Stevenage in first-half stoppage time.

[59] Hylton scored a penalty early into the second half, before Berry completed his hat-trick 10 minutes later with a 20-yard curling shot, and with further goals from Gambin and James Justin in stoppage time, the match finished 7–1.

[62] A 3–0 defeat at home to Coventry City saw Luton's nine-match unbeaten run in the league come to an end, with the visitors taking the lead in the 17th minute through Marc McNulty with a header.

[63] Luton progressed to the second round of the EFL Trophy as Southern Group F winners after a 2–1 win away to AFC Wimbledon, in which they took the lead in the 12th minute when Andrew Shinnie's shot beat goalkeeper Joe McDonnell.

[65] Luton won 1–0 in their first-round match of the FA Cup at home to Portsmouth, in which Collins scored the only goal in first-half stoppage time with a left-footed shot into the bottom corner.

[66] Potts scored a header from Sheehan's corner to give Luton an 11th-minute lead away to Cheltenham Town, before the home team equalised through Jamie Grimes on 37 minutes.

[67] Elliot Lee put Luton back in front in the 86th minute when Sheehan's free kick hit the wall and fell to him inside the six-yard box before shooting into the bottom corner, and Will Boyle equalised for Cheltenham in the seventh minute of stoppage time from close range following Jerell Sellars' corner, the match finishing a 2–2 draw.

[68] Luton moved back into the automatic promotion places after beating Cambridge United 7–0 at home, in which they took the lead after Potts scored from close range in the 24th minute.

[71] November ended with a third successive league win after Luton won 2–1 away to Crewe Alexandra, and took the lead in the 63rd minute with a Hylton shot that went in off the crossbar.

[73] Cotter was recalled from his loan at Hitchin, and started in Luton's 4–0 home win over West Ham United U21 in the EFL Trophy second round.

[74] Cotter extended the lead in the 86th minute with a drilled shot from 15 yards, before Jordan Cook finished the scoring in stoppage time when an attempted clearance from goalkeeper Nathan Trott rebounded off him and into the net.

[79] Berry scored from 25 yards to give Luton a 40th-minute lead, before Collins made it 2–0 with a header into the bottom corner from Sheehan's free kick in the 61st minute.

[82] Sheehan was sent off in the fourth minute after an altercation with Matt Rhead, with Michael Bostwick scoring the resulting 25-yard free kick to give Lincoln an early lead.

[83] Luton were eliminated from the EFL Trophy after a 7–6 penalty shoot-out defeat to Peterborough United in the third round, and their best chance of the match came in the 37th minute when Cook's header hit the post from Cornick's cross.

[85] Isted and James joined Chesham United and Hitchin of the Southern League Premier Division on a one-month youth loan and work experience respectively.

[86][87] Mullins scored a 64th-minute header from Olly Lee's free kick as Luton beat Morecambe 1–0 at home, moving six points clear at the top of the table.

[89] Luton recorded a second successive 1–0 victory away to Grimsby Town, with Collins scoring a 49th-minute winner from close range after goalkeeper Ben Killip tipped a Berry free kick onto the crossbar.

[90] Luton had fallen two goals behind at home to Wycombe Wanderers by the 39th minute of a 3–2 defeat, who scored through Paris Cowan-Hall and Nathan Tyson.

[91] Defender Lloyd Jones and forward Jake Jervis were signed from Liverpool and Plymouth Argyle respectively on two-and-a-half-year contracts for undisclosed fees, while midfielder Flynn Downes joined on loan from Ipswich Town until the end of the season.

[111] Elliot Lee gave Luton a fourth-minute lead away to Yeovil Town from Hylton's flicked header, before the latter scored a penalty in the 20th minute after he was fouled by Ryan Dickson, who was sent off.

[112] François Zoko was then shown a red card on 32 minutes for an off-the-ball incident with McCormack, before Hylton made the score 3–0 from the rebound shortly before half-time after his initial shot from Collins' cross had hit the post.