The 2017–18 Nicholls State Colonels women's basketball team represented Nicholls State University during the 2017–18 NCAA Division I women's basketball season.

The Colonels, led by tenth year head coach DoBee Plaisance, played their home games at Stopher Gym and were members of the Southland Conference.

They won their first Southland women's tournament and earned an automatic trip to their first NCAA women's tournament in school history, where they lost in the first round to Mississippi State.

The Colonels finished the season 10–20 overall and 7–11 in Southland play a three-way tie for eighth place.

They lost in the first round of the Southland women's tournament to McNeese State.