The 2017–18 season was Sepahan's 17th season in the Pro League, and their 24nd consecutive season in the top division of Iranian Football and 64th year in existence as a football club.

They competed in the Hazfi Cup.

Sepahan was captained by Hossein Papi.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.