The 2017–18 USC Upstate Spartans women's basketball team represented the University of South Carolina Upstate in the 2017–18 NCAA Division I women's basketball season.

The Spartans, led by thirteenth year head coach Tammy George, played their games at G. B. Hodge Center and were members of the Atlantic Sun Conference.

They lost in the quarterfinals of A-Sun Tournament to Lipscomb.

All home games and conference road are shown on ESPN3 or A-Sun.TV.

Non conference road games are typically available on the opponents website.