The team won their second straight American League Central title, but were upset by the New York Yankees in five games in the ALDS despite holding a 2–0 series lead.
This series was highlighted by a 9−6 win on April 5 in which Francisco Lindor hit his first career grand slam during the five-run 9th inning in which the Indians erased a 6-4 deficit.
The Indians finished April 14-10, with the bright spot of the month being a 5-0 road trip against the Chicago White Sox and the Minnesota Twins.
SP Corey Kluber would return to the Indians' rotation on June 1, as he would go six shutout innings en route to an 8-0 win over the Oakland Athletics.
José Ramírez collected nine consecutive multi-hit games in June, the longest such streak for an Indians player since Roy Hughes in 1936.
[5] Ramírez was named AL Player of the Week for the first time in his career on June 18, after batting .516 with 16 hits, three home runs, seven RBI and a stolen base.
[7] On July 2, OF Michael Brantley, SP Corey Kluber, SS Francisco Lindor, RP Andrew Miller, and 3B José Ramírez were all named to the American League team for MLB All-Star Game, played at Marlins Park in Miami.
[9] When Jason Kipnis sustained a hamstring injury on July 9, the Indians placed him on the 10-day DL,[10] and shifted Ramírez to cover second base to replace him for much of the remainder of the season.
[5] The Indians started July 6−8, including a tough west-coast trip following the All-Star break that saw the team go 1−5 against the last place Oakland Athletics and San Francisco Giants.
[12] On August 3, Corey Kluber struck out 11 batters and gave up three hits in a 5−1 complete game win against the New York Yankees, making him the fourth pitcher ever to get eight or more strikeouts in 12 consecutive starts.
[14] On September 3, José Ramírez tied a major league record with five extra-base hits, which included three doubles and two home runs.
[16] Corey Kluber pitched his third shutout of the season with 12 strikeouts on September 12, against the Detroit Tigers, giving the Indians their 20th consecutive win, matching the 2002 Oakland Athletics for the American League record.
[18] The Indians would win a 22nd straight game the next day, but their streak was snapped on September 15, with a 4-3 loss to the Kansas City Royals.