The Lions got on the board in the second quarter with a six-yard touchdown pass from Matthew Stafford to Marvin Jones Jr., and a 58-yard field goal from Matt Prater to make the score 10–9 in favor of Arizona at half-time.
Stafford connected with Golladay again minutes later with a 45-yard touchdown pass, then Miles Killebrew returned an interception 35 yards for the Lions' final points.
The Giants tied the game in the second quarter with an 18-yard touchdown pass from Eli Manning to Evan Engram, but the Lions took the lead back (which they kept for the rest of the game) with a seven-yard touchdown pass from Stafford to Eric Ebron, and a 56-yard field goal by Matt Prater to make the score 17–7 in favor of Detroit at half-time.
The Lions responded with an 11-yard touchdown pass from Matthew Stafford to Golden Tate, and a 35-yard field goal from Prater to tie the game at 23.
The Lions' attempted comeback failed when a touchdown pass from Stafford to Tate was overturned with eight seconds remaining in the game.
The Vikings responded a few minutes later with a five-yard rushing touchdown by Dalvin Cook to make the score 7–3 in favor of Minnesota at half-time.
Next, Detroit regained the lead with a three-yard rushing touchdown by Ameer Abdullah, followed by a two-point conversion pass from Matthew Stafford to T. J. Jones.
Detroit's Glover Quin forced another fumble by Adam Thielen with under two minutes left in the game, which was recovered by Tahir Whitehead to end Minnesota's attempt at a possible game-tying drive.
The Lions responded with 14 points in the fourth quarter via two touchdown receptions from Matthew Stafford to Darren Fells, from four-yards and 20-yards respectively, making the final score 27–24 in favor of Carolina.
The Saints regained the lead via a 20-yard touchdown pass from Drew Brees to Ted Ginn Jr. and a 41-yard field goal from Wil Lutz.
The Saints scored 14 points in the third quarter via a two-yard touchdown pass from Brees to Michael Hoomanawanui and a 27-yard interception return from Marshon Lattimore.
The Lions' attempted comeback failed when Stafford's pass intended for Eric Ebron was intercepted in the end zone by Cameron Jordan, making the final score 52–38 in favor of New Orleans.
The Steelers responded with a five-yard touchdown run from Le'Veon Bell, to make the score 12–10 in favor of Detroit at half-time.
The Steelers scored 10 points in the third quarter via a 38-yard field from Boswell, and a 97-yard touchdown pass from Ben Roethlisberger to JuJu Smith-Schuster.
The Lions responded with a 19-yard field goal from Prater in the fourth quarter, making the final score 20–15 in favor of Pittsburgh.
The Lions took an early lead on their opening drive of the first quarter, which they kept the rest of the game, via a 25-yard touchdown pass from Matthew Stafford to Marvin Jones Jr.
Matthew Stafford recorded his 200th career touchdown in the first quarter of the game, becoming the fourth quarterback in NFL history to do so before turning 30 years old, a list also occupied by Brett Favre, Dan Marino, and Peyton Manning.
The Browns scored 10 points in the first quarter via a 23-yard field goal from Zane Gonzalez, and a 19-yard touchdown pass from DeShone Kizer to Kenny Britt.
The Bears scored 10 points in the first quarter via a 23-yard field goal from Connor Barth, and a one-yard touchdown pass from Mitchell Trubisky to Adam Shaheen.
The Lions responded with 10 points in the second quarter via a 32-yard field goal from Matt Prater and a six-yard touchdown pass from Matthew Stafford to Marvin Jones Jr.
The Vikings extended their lead in the second quarter via a 22-yard touchdown pass from Keenum to Rudolph to make the score 20–10 in favor of Minnesota at half-time.
On the Vikings' ensuing drive, Forbath's 25-yard field goal attempt was blocked by Darius Slay and recovered by Nevin Lawson and returned for a 77-yard touchdown, which was then nullified due to an offside penalty on Slay, making the final score 30–23 in favor of Minnesota, snapping the Lions' three-game winning streak and snapping the team's four-game Thanksgiving Day win streak.
Matt Prater kicked a 46-yard field goal with 20 seconds left in the game, making the final score 24–21 in favor of Detroit.
In week 15, the Lions donned brand new all-silver uniforms and hosted a Saturday evening rematch with their division rivals, the Chicago Bears.
The Lions extended their lead in the second quarter via a 31-yard field goal from Prater, and a three-yard touchdown pass from Matthew Stafford to T. J. Jones.
The Bears got on the board via a 41-yard field goal from Mike Nugent with two seconds remaining in the first half, to make the score 13–3 in favor of Detroit at half-time.
The Bengals' Randy Bullock kicked a pair of field goals in the second quarter, from 29-yards and 27-yards, respectively, to make the score 7–6 in favor of Detroit at half-time.
However, Cincinnati regained the lead when they added ten more points with a 51-yard field goal from Bullock and a 12-yard touchdown run from Giovani Bernard to make the final score 26–17 in favor of the Bengals.
To finish the season, the Lions hosted a rematch with their divisional rivals, the Green Bay Packers, on New Year's Eve.
The teams exchanged field goals in the first quarter, one from Green Bay's Mason Crosby from 41-yards, and one from Detroit's Matt Prater from 28-yards.