The sixth edition of Gent–Wevelgem – In Flanders Fields was held on Sunday 26 March 2016.

It was the fourth race of the 2017 UCI Women's World Tour season.

Finland's Lotta Lepistö (Cervélo–Bigla Pro Cycling) won the race in a bunch sprint finish ahead of home rider Jolien D'Hoore (Wiggle High5) American Coryn Rivera (Team Sunweb) completed the podium.

[4][a] Race director Hans De Clercq stated that it is a tribute to the historical significance of the Kemmelberg, as it is that road being used the first time the Kemmelberg was included in the men's race, in 1955.

They have given it an overall score of 183 points, which is more than the Koppenberg, the Muur van Geraardsbergen or the traditional Kemmelberg road.