Michigan ended Big Ten Conference play with a 5–4 record to finish in fourth in the Eastern Division.

Michigan struggled to find consistent play at quarterback throughout the year; with Wilton Speight suffering a season ending injury in the team's week 4 contest at Purdue, John O'Korn, and Brandon Peters each received significant playing time in his stead.

Linebacker Devin Bush Jr. and linemen Rashan Gary and Chase Winovich also received first-team all-conference honors.

The Maize team's Kyle Seychel kicked a 31-yard field goal as time expired for the 31–29 win.

[3] The Michigan football team traveled to Italy for a week in late April for training, sight-seeing, and brand exposure.

The radio announcers were Jim Brandstatter (in his final season with the team) with play-by-play, Dan Dierdorf with color commentary, and Doug Karsch with sideline reports.

[28] To open the season, Michigan faced the Florida Gators in a neutral site game in Arlington, Texas in the Advocare Classic.

Michigan then scored 20 unanswered points in the second half, via a three-yard touchdown run from Karan Higdon and 30-yard field goal from Nordin in the third quarter.

Michigan extended its lead in the fourth quarter via a 50-yard field goal from Nordin and a fumble recovery in the end-zone by Noah Furbush.

Cincinnati reduced Michigan's lead to seven points via a one-yard touchdown run from Mike Boone.

[36] Michigan's honorary captain for the game was ESPN NFL Insider and 1989 alumni Adam Schefter.

Wilton Speight surpassed the 3,000-yard passing mark for his career, becoming the 13th quarterback in Michigan history to reach the milestone.

Michigan added 10 points in the fourth quarter via a 36-yard field from Nordin and a 36-yard touchdown run from Karan Higdon.

Kicker Quinn Nordin went 5-for-5 on field goal attempts to tie Michigan's single game record.

[38] Following its game against Air Force, Michigan began its conference schedule when it traveled to West Lafayette, Indiana to face the Purdue Boilermakers.

[42] After a bye week, the Wolverines hosted their in-state rival, the Michigan State Spartans, in the battle for the Paul Bunyan Trophy.

Michigan reduced the Spartans lead to four points in the third quarter via a one-yard touchdown run from Khalid Hill.

Michigan's attempted comeback failed when O'Korn's Hail Mary pass was incomplete to end the game.

Michigan added ten points in the second quarter via a 38-yard field goal from Nordin and a 12-yard touchdown run from Karan Higdon.

Indiana responded with ten points in the fourth quarter via an eight-yard touchdown pass from Peyton Ramsey to Whop Philyor, and a field goal from Oakes as time expired to tie the game and force overtime.

[51] Following its clash with Indiana, Michigan traveled to University Park, Pennsylvania to face the Penn State Nittany Lions.

[55] A group of Penn State students caused controversy when it displayed a sign saying Michigan's quarterbacks are worse than the Flint water crisis.

Karan Higdon and Ty Isaac both surpassed 100-yards rushing, marking the 40th time in program history that Michigan had a pair of 100-yard rushers.

Michigan responded with a one-yard touchdown run from Ben Mason in the second quarter to tie the game at half-time.

Michigan opened the scoring in the second half via a 39-yard field goal from Quinn Nordin, to take its first lead of the game.

Following its road finale against Wisconsin, Michigan hosted its arch-rivals, the Ohio State Buckeyes, in the 114th meeting of "The Game".

Michigan extended its lead in the second quarter via a three-yard touchdown pass from John O'Korn to Sean McKeon.

Ohio State scored 10 points in the fourth quarter via a 44-yard field goal from Sean Nuernberger, and a 25-yard touchdown run from Mike Weber.

[81] Michigan's honorary captains for the game was former Wolverine and 1997 Heisman winner Charles Woodson, and alumnus Dao-Yi Chao, creative director and co-founder of Public School New York (PSNY).

Michigan scored 10 points in the third quarter via a one-yard touchdown run from Ben Mason, and a 48-yard field goal from Nordin.