The Tigers played their home games at Faurot Field in Columbia, Missouri and competed in the Eastern Division of the Southeastern Conference (SEC).

They were led by second-year head coach Barry Odom.

On November 24, quarterback Drew Lock broke the SEC passing record for touchdowns in a season with 43, in a 48–45 win over Arkansas.

Sources: Missouri announced its 2017 football schedule on September 13, 2016.

The Tigers will host SEC foes Auburn, Florida, South Carolina, and Tennessee, and will travel to Arkansas, Georgia, Kentucky, and Vanderbilt.