Playing with eight teams spread across the eastern and southern United States (with one team in Mexico), the league's regular season kicked off on March 17, 2017, when the Columbus Lions hosted the Jacksonville Sharks and lost 41–56.
The regular season ended 14 weeks later on June 17, 2017, with the Sharks hosting the Monterrey Steel and the Lions visiting the Georgia Firebirds.
Four of the teams (Corpus Christi Rage, Dayton Wolfpack, High Country Grizzlies and Monterrey Steel) were playing their inaugural seasons, with three teams (Columbus Lions, Georgia Firebirds, Lehigh Valley Steelhawks) joining from the now-defunct American Indoor Football, and one team (Jacksonville Sharks) joining from the Arena Football League.
However, in order to satisfy their arena contract from their time in AFL, the Jacksonville Sharks were given eight home games, while the Corpus Christi Rage and Dayton Wolfpack were each only given five home games to balance the schedules.
This was changed again when the Wolfpack were apparently unable to secure an arena lease, despite announcing they would play at the Nutter Center.