The Liberal Democrats, led by Tim Farron saw their previous leader Nick Clegg lose his seat; as Sheffield Hallam was gained by the Labour candidate, Jared O'Mara.
They also gained some seats, including the recovery of Twickenham by former Business Secretary Sir Vince Cable who had lost it to the Conservatives two years previously.
Crewe and Nantwich was a gain for Labour, with tutor and activist Laura Smith defeating children and families minister Edward Timpson.
Commons leader Dr David Lidington, veterans minister Lieutenant Colonel Mark Lancaster and former attorney-general Dominic Grieve were re-elected.
DWP ministers Damian Hinds and Penny Mordaunt, May's own PPS George Hollingbery, Cabinet Office undersecretary Caroline Nokes and assistant whip Steve Brine were re-elected.
In Devon Labour made one gain in Plymouth Sutton and Devonport, trade unionist Luke Pollard defeating Oliver Colvile.
The former armed forces minister Sir Nick Harvey attempted to regain the constituency of North Devon but the Conservative Peter Heaton-Jones held it by a margin of 4,332.
In Dorset all eight Conservative MPs were re-elected, including the counter-terrorism minister Tobias Ellwood and former Lancaster chancellor Sir Oliver Letwin.
Gisela Stuart retired and was succeeded in Birmingham Edgbaston by Sandwell councillor Preet Gill, making her the first female Sikh in the House of Commons.
Their six MPs included communities secretary Sajid Javid and three junior ministers (Harriett Baldwin, Robin Walker and Mark Garnier).
Five MPs were elected, including Philip Dunne (incumbent Minister of State for Health) and Owen Paterson (who had headed the Northern Ireland Office and Defra under the coalition).
In Warwickshire the Labour party gained Warwick and Leamington (county councillor Matt Western defeated Chris White, ending seven years of Conservative ascendancy.)
The Conservatives held the five other seats, electing attorney-general Jeremy Wright, DCLG minister Marcus Jones and PPS Mark Pawsey.
In the East Riding of Yorkshire, the four Conservative MPs (David Davis, Graham Stuart, Greg Knight and Andrew Percy) were all re-elected with substantially increased shares of the vote.
In West Yorkshire five Conservatives (Craig Whittaker, Alec Shelbrooke, Andrea Jenkyns, Stuart Andrew and Philip Davies) were re-elected.
Labour held the fourteen seats it had won in 2015, returning shadow Lord Chancellor Richard Burgon and leadership contender Yvette Cooper as well as actress Tracy Brabin who had been elected the previous autumn following the murder of Jo Cox.
No constituencies changed allegiance in North Yorkshire: Labour's Rachael Maskell was re-elected in York Central while all seven other seats were held by the Conservatives, including vice-chamberlain and junior whip Julian Smith and transport minister Andrew Jones.